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15,800+ Happy Customers

Spore-Forming Probiotics, Next-Generation Prebiotics, Patented Postbiotics, and Targeted Polyphenols


The first and only 4-in-1 microbiome support formula that replaces an entire cabinet of gut supplements with one comprehensive solution.


✓ 4-in-1 formula with probiotics that actually survive stomach acid


✓ Transform bloating, brain fog, and energy crashes within weeks


✓ Clinically-proven ingredients used by thousands of patients

✓ Optimize your microbiome and strengthen intestinal barrier integrity

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See What Others Are Saying About Biome Protect

  • "I’ve only been taking Biome Protect for a week and already notice significant results. I was struggling with bloating and constipation after meals, and within a few days have much healthier, easier, and fuller BMs. I also feel a little more energy after my meals. Looking forward to more benefits with longer use."

    —Mary

  • "I have been told I have IBS so I've struggled with bloating and constipation for years. I tried [competitor probiotic] for a few months but it seemed to just stop working as well. I tried Adapt because I like that its not just about the gut but focuses on the gut. Its been a few weeks and it's already working better. I'm regular, no bloating and I feel good all around!"

    —Jasmine

  • "I definitely noticed a difference since starting Biome Protect and believe it’s due to the type of probiotic strain used. Daily bowel movements come easier, are better formed and bloating and gut uneasiness lessened. So glad to have tried this product that I’ll continue using."

    —Paula

Introducing Biome Protect: The First 4-in-1 Microbiome Support Formula

Biome Protect is the first and only product on the market that combines all four essential elements your gut needs to thrive in one comprehensive formula—what we call "Gut Health 3.0".

Unlike other gut health supplements that only provide basic probiotics (which die in stomach acid) or require you to take multiple products, Biome Protect includes:

✓ Spore-forming probiotics that survive digestion

✓ Next-generation prebiotics that work at 1/300th the dose

✓ Patented postbiotics that fuel your gut cells

✓ Targeted polyphenols from ancestral sources

Biome Protect is the clinical breakthrough that replaces an entire cabinet of gut supplements with one scientifically-formulated solution.

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What makes Biome Protect stand out?

  • Probiotics that survive stomach acid

    Biome Protect contains Bacillus coagulans, a spore-forming probiotic that survives stomach acid (unlike 95% of regular probiotics). This means the beneficial bacteria actually reach your intestines alive, where they can improve digestive comfort, enhance immune function, and even boost cognitive performance.

  • Prebiotics without the bloating

    Biome Protect features FortiPhage™, a next-generation prebiotic that works at just 15 mg—that's 1/300th the dose of traditional fiber prebiotics. It increases good bacteria up to 6-fold without causing the bloating, gas, and discomfort typical of fiber-based prebiotics.

  • Postbiotics that fuel your gut

    Biome Protect includes CoreBiome® tributyrin, a patented form of butyrate that survives stomach acid and delivers this essential fuel throughout your entire digestive system. Butyrate directly energizes intestinal cells, strengthens the gut barrier, and supports healthy immune response.

  • Polyphenols from ancestral sources

    Biome Protect contains targeted polyphenols from cranberry, pomegranate, grape, and blueberry—the same compounds our ancestors consumed regularly. These specific polyphenols increase beneficial bacteria like Akkermansia, enhance butyrate production, and optimize your microbiome at the cellular level.

Formulated to Transform Your Gut Health from the Inside Out

After treating thousands of patients over 15 years, I discovered why most gut health solutions fail—and created the clinical breakthrough that has helped thousands of people thrive. Biome Protect was formulated to address the root causes of gut dysfunction, not just mask symptoms.

Unlike traditional approaches that rely on basic probiotics (which die in stomach acid) or require multiple supplements working against each other, Biome Protect provides four synergistic elements that enhance each other's effectiveness. This "Gut Health 3.0" approach optimizes your microbiome, strengthens your gut barrier, and supports whole-body health.

Biome Protect promotes better digestion, sustained energy, mental clarity, stronger immunity, and balanced mood—transforming your health from the foundation up.

Here are some benefits you can expect from this one-of-a-kind product:

✓ Eliminates bloating and digestive discomfort. Say goodbye to the uncomfortable fullness, gas, and unpredictable digestion that disrupts your day. Feel light, comfortable, and confident after meals.

✓ Restores consistent energy levels. No more afternoon crashes or brain fog. Experience sustained mental clarity and physical energy throughout your entire day.

✓ Strengthens your immune resilience. Get sick less often and bounce back faster when you do. Build robust defenses against whatever life throws your way.

✓ Promotes clearer skin and balanced mood. Watch as skin issues clear up and mood swings stabilize. Feel like yourself again—calm, focused, and radiantly healthy from the inside out.

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Biome Protect contains:

SPORE-FORMING PROBIOTICS (BACILLUS COAGULANS)

SPORE-FORMING PROBIOTICS (BACILLUS COAGULANS)

2 billion CFU of Bacillus coagulans that survive stomach acid. Unlike 95% of regular probiotics that die before reaching your intestines, these spore-forming bacteria create a protective shell and activate exactly where needed for maximum effectiveness.

NEXT-GENERATION PREBIOTICS (FORTIPHAT™)

NEXT-GENERATION PREBIOTICS (FORTIPHAT™)

15 mg of FortiPhage™ bacteriophages that work at 1/300th the dose of fiber prebiotics. Selectively targets unwanted bacteria while increasing beneficial species up to 6-fold—without any bloating, gas, or digestive discomfort.

PATENTED POSTBIOTICS (COREBIOME®)

PATENTED POSTBIOTICS (COREBIOME®)

300 mg of CoreBiome® tributyrin, a time-released form of butyrate that survives stomach acid. Directly fuels intestinal cells, strengthens the gut barrier, and supports healthy immune response throughout your entire digestive system.

TARGETED POLYPHENOLS

TARGETED POLYPHENOLS

Concentrated extracts from cranberry, pomegranate, grape, and blueberry. These ancestral compounds increase Akkermansia muciniphila, enhance butyrate production, and optimize your microbiome at the cellular level.

Biome Protect gives you 4 clinically-proven gut health ingredients in a single product—at a significantly lower price than you'd pay for them separately.

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Adapt Naturals Biome Protect

Bio-Avail Biome Protect is the most comprehensive gut health formula on the market. No other product combines probiotics, prebiotics, postbiotics, and polyphenols in one scientifically-formulated solution.

  • 4-in-1 formula that replaces an entire cabinet of gut supplements
  • Spore-forming probiotics that actually survive stomach acid
  • Next-generation prebiotics that work without bloating
  • Patented postbiotics that fuel your gut cells directly
  • Targeted polyphenols from ancestral sources
  • Formulated by globally-renowned Functional Medicine clinician Chris Kresser
  • Made without gluten and GMOs
  • Manufactured in the US in a certified GMP facility

Signs You Need Biome Protect

Gas, bloating, or other digestive problems

Brain fog, poor focus, or mental fatigue

Skin issues that seem unrelated to diet

Mood swings, anxiety, or feeling "off"

Getting sick more often than you should

Irregular bowel movements or inconsistent stool quality

What You'll Feel Using Biome Protect

  • Better digestion and no more bloating

  • Mental clarity and sharper focus

  • Stronger immune defenses against daily challenges

  • Balanced mood and emotional wellbeing

  • Clearer, healthier-looking skin

  • Regular, consistent bowel movements

  • Support maintaining normal weight and metabolic function

Meet Chris Kresser, your
Trusted Health & Wellness Guide

Founder & Functional Medicine Clinician

  • Globally renowned expert with over 15 years of experience
  • Dedicated to helping people improve their health by addressing modern challenges and nutrient gaps

Author & Educator

  • Treated thousands of patients
  • Trained more than 2,000 healthcare professionals
  • Gained valuable insights into functional medicine and nutrition

"I'm excited about Adapt Naturals and Bio-Avail Multi. Chris is a leading clinician, educator, and researcher in the Functional Medicine space. I've learned a lot from him about nutrition and supplements over the years, and I know his products are fueled by high-quality, evidence-based ingredients you can trust."

Dr. Mark Hyman MD

14-time New York Times best selling author and founder of the Cleveland Clinic Center for Functional Medicine

"Chris Kresser is one of the sharpest minds in the functional / integrative medicine space. I have reached out to Chris many times when working to unravel my own health journey and his insights have always been incredible. Given all that, I'm super excited for the release of Adapt Naturals line of supplements, especially Bio-Avail Multi. Chris and I are aligned in that we believe the bulk of our nutrition should come from whole, minimally processed foods, but we also recognize that the right supplement, at the right time can 'change everything.'"

Robb Wolf

Former research biochemist and 2-time New York Times bestselling author of The Paleo Solution and Wired To Eat.

"I can't think of a better person to formulate supplements than Chris Kresser. I trust his ability to skillfully combine ancestral wisdom with modern science and cutting-edge research. Taken together, the products offer a well-rounded and complete way to boost your nutritional status. I am excited about this high-quality, comprehensive new product line - I strongly recommend it!"

Dr. Akil Palanisamy MD

Harvard-trained physician, author, speaker, and holistic medicine expert in integrative and functional medicine

"I trust Chris Kresser with my life, and you will too."

Sara Gottfried MD

Harvard Trained Physician and New York TimesBestselling author of The Hormone Cure

Choose Your Biome Protect Package

FREE pouch of Bio-Avail Colostrum+ included. Plus, free shipping when you order 3 or more pouches!

 30-Day Supply

1 Pouch of Biome Protect +

1 FREE Bio-Avail Colostrum+ pouch

$127.87 $57.93
You're saving: $69.94
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90-Day Supply

3 Pouches of Biome Protect +

1 FREE Bio-Avail Colostrum+ pouch

$243.73 $159.61
You're saving: $84.12
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180-Day Supply

6 Pouches of Biome Protect +

1 FREE Bio-Avail Colostrum+ pouch

$417.52 $250.51
You're saving: $167.01
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About your FREE Bio-Avail Colostrum+

For patients with severe gut permeability issues, I discovered that adding colostrum accelerated healing dramatically. Bio-Avail Colostrum+ provides:

✓ Immunoglobulins that neutralize harmful bacteria

✓ Lactoferrin for natural antimicrobial support

✓ Growth factors that directly repair intestinal lining

✓ Enhanced with beta-glucan for immune training

When combined with Biome Protect, it creates powerful synergy: Biome Protect optimizes your microbiome while Bio-Avail Colostrum+ repairs and seals your gut barrier.

60-Day Money Back Guarantee

60-Day Money Back Guarantee

We're confident you'll love our products, but if you're not completely satisfied, we offer a 60-day, 100% money-back guarantee on all purchases. Simply contact us for a full refund, no questions asked. Buy with confidence knowing you're covered by our guarantee.

The Adapt Naturals Standard

The Adapt Naturals Standard

In our increasingly toxic world, the last thing you want to worry about is a lot of artificial junk in your supplements. Adapt Naturals supplements are made with the cleanest possible ingredients, without gluten or GMOs. Our products are manufactured in a U.S. facility that meets the NSF’s rigorous GMP regulatory standards.

Third Party Lab-Tested

Third Party Lab-Tested

At Adapt Naturals, all of our products are third-party tested and validated, and we are always happy to share these results with customers. We want you to have full confidence that you’re getting exactly what you think you are with each purchase.

Learn More

Your Questions Answered

Take 2 capsules daily, preferably with a meal. For best results, take consistently every day.

No, Biome Protect is shelf-stable and does not require refrigeration. Store in a cool, dry place.

Some people may notice improvements in digestion and energy within a few days. However, for full benefits, we recommend taking Biome Protect consistently for at least 30-60 days.

Yes, Biome Protect is designed to complement other supplements, including other probiotic strains. However, if you're taking any medications, please consult with your healthcare provider before starting any new supplement regimen.

Yes, Biome Protect is formulated for safe, long-term use. The ingredients are naturally occurring compounds that support overall gut health and wellness.

If you are pregnant, nursing, or taking blood thinners or anti-coagulant medications, please consult with your healthcare provider before using Biome Protect.

Yes, all Adapt Naturals products, including Biome Protect, undergo rigorous third-party testing for purity and potency. Most importantly, we transparently share these results with our customers by posting Certificates of Analysis (CoAs) and test results on our website. This level of openness is almost unheard of in the supplement industry. It allows you to see exactly what’s in the product you’re putting into your body.Click here to view the most recent CoA and test results.

Customer Reviews

Based on 180 reviews
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A
Ari Weise
Works really well!

I’ve been taking Biome Protect for about 4 months now and it’s made such a difference. My digestion is smoother, I’m less bloated, my skin looks clearer, and my immune system feels stronger. I love that it’s clean, natural, and easy to take. Definitely recommend!

L
Linda Erfle
Cures bloating!

I love biome protect! I feel so much better since starting it two months ago. Im a GI nurse, and I'm recommending this to everyone who complains of bloating....great for constipation as well!

Hi Linda,

We’re so glad you’re feeling better since starting Biome Protect! This 4-in-1 formula combines probiotics, prebiotics, postbiotics, and polyphenols to help support digestive comfort, regularity, and a healthy gut environment. Thank you for recommending it to others—it means a lot to us.

M
Michelle
So far so good

I’ve been taking this for 2 weeks now. I take another pro/prebiotic, Seed, so I’m only taking 1 of these.
I find my bowel movements are more consistent and I feel less hungry.

Hi Michelle,

That’s great to hear! Biome Protect is designed to help maintain regularity and support a healthy gut environment with its combination of targeted probiotic strains, prebiotics, postbiotics and plant-based polyphenols. Thanks for sharing your early experience—we hope the benefits continue to build.

A
Andrea Theriault
Amazing.

I’ve had gut issues all my life and have tried everything. FODMAP, dairy, gluten, probiotics, supplements, and nothing helped my symptoms of IBS, which are a churning stomach, nausea and fatigue.
With Biome Protect ( I’ve been on for 5 months, It’s literally taken it all away! If I start to have any symptom at all- it’s very short lived and mild. I’m very happy with this product.

Hi Andrea,

We’re thrilled you’ve found Biome Protect so supportive! This all-in-one formula combines prebiotics, postbiotics, probiotics and polyphenols that are immune-supporting compounds which promote a balanced gut environment and overall well-being. Five months of consistent use is such a great foundation—thank you for trusting us on your journey.

L
Lindsay Joyce
Quick and noticeable

After just a week of use I already can see an improvement in my digestion! I know the results will get better with more time but this is really promising so far :)

Hi Lindsay,
It’s wonderful to hear you’ve noticed digestive support so quickly with Biome Protect! We can’t wait to hear how you feel after a few more weeks.

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