The Hormonal Sleep Rescue System

Includes: Bio-Avail Omega+ + Bio-Avail Collagen+

Rebuild Your Sleep Architecture. Restore Your Hormonal Balance.

  • Hormonal Sleep Rescue System
  • Hormonal Sleep Rescue System

The Hormonal Sleep Rescue System

Includes: Bio-Avail Omega+ + Bio-Avail Collagen+

Rebuild Your Sleep Architecture. Restore Your Hormonal Balance.

A two-phase protocol designed for women navigating perimenopause, menopause, or hormone-related sleep disruption. This system combines Bio-Avail Omega+ and Bio-Avail Collagen+ to restore your circadian rhythm, rebuild overnight repair pathways, and help you sleep through the night again—naturally.

  • Support healthy hormonal balance without synthetic hormones

  • Fall asleep faster and stay asleep longer—without melatonin

  • Reduce 3am cortisol spikes and restless nights

  • Wake energized and clear-headed, not groggy or foggy

Delivers every

Clinically-formulated | 60-Day Guarantee | Save 30% on your first subscription order

90-Day Returns

RESET YOUR CIRCADIAN RHYTHM

Natural Sleep-Wake Balance

Precision omega-3s and curcumin support your body's natural sleep-wake cycles without dependency or sedation.

REPAIR WHILE YOU REST

Overnight Cellular Recovery

Collagen peptides rich in glycine promote deeper sleep phases and overnight cellular repair for hormone production, tissue regeneration, and detoxification.

RELIEVE NIGHTTIME RESTLESSNESS

Calm Your Nervous System

Reduce cortisol spikes and support neurotransmitter balance with a powerful trio of high-EPA omega-3s, thymoquinone-rich black seed oil, and bioavailable curcumin.

WAKE REFRESHED, NOT GROGGY

Natural Morning Clarity

No synthetic hormones. No melatonin hangovers. Just better sleep from the inside out.

Key Ingredients

BIO-AVAIL OMEGA+

BIO-AVAIL OMEGA+

EPA/DHA Omega-3s (3:2 ratio) – supports circadian rhythm regulation and stress recovery

NovaSOL® Curcumin – 185x more bioavailable to reduce inflammation and nighttime restlessness

ThymoQuin™ Black Seed Oil – clinically shown to improve sleep onset and duration in just 7 days

BIO-AVAIL COLLAGEN+

BIO-AVAIL COLLAGEN+

10g Grass-Fed Collagen – rich in glycine, proline, and hydroxyproline to support deeper sleep

2kDa Molecular Weight – optimized for rapid absorption and overnight repair

Hormonal Repair Support – nutrients needed for healthy estrogen metabolism, neurotransmitter synthesis, and collagen replenishment

Signs You Need The Hormonal Sleep Rescue System

You wake between 2-4am with racing thoughts or night sweats

You feel exhausted despite "sleeping" 7+ hours

You've tried melatonin and feel worse

You're in perimenopause, menopause, or beyond

You feel like a stranger in your own body

What you'll feel with The Hormonal Sleep Rescue System

  • Sleep through the night without 3am wakeups

  • Wake before your alarm feeling rested and alert

  • Notice smoother skin, better mood, and calmer mornings

  • Fewer night sweats and more dream recall (a sign of healthy REM)

  • Energy and focus that lasts past 2pm

90-Day Money Back Guarantee

90-Day Money Back Guarantee

We're confident you'll love our products, but if you're not completely satisfied, we offer a 90-Day, 100% money-back guarantee on all purchases. Simply contact us for a full refund, no questions asked. Buy with confidence knowing you're covered by our guarantee.

The Adapt Naturals Standard

The Adapt Naturals Standard

In our increasingly toxic world, the last thing you want to worry about is a lot of artificial junk in your supplements. Adapt Naturals supplements are made with the cleanest possible ingredients, without gluten or GMOs. Our products are manufactured in a U.S. facility that meets the NSF's rigorous GMP regulatory standards.

Third-Party Lab-Tested with Transparent Results

Third-Party Lab-Tested with Transparent Results

We conduct third-party testing on all our products to verify their purity, potency, and safety. Most importantly, we transparently share these results with our customers by posting Certificates of Analysis (COAs) and test results directly on our website. We want you to have full confidence that you're getting exactly what you think you are with each purchase.

See Test Results

Why Choose The Hormonal Sleep Rescue System?

After 15 years treating women in perimenopause and menopause, Chris Kresser saw a common thread: their sleep wasn't just disrupted—it was hormonally hijacked. Night sweats, 3am wakeups, and restless sleep weren't being fixed by melatonin or sedatives.

The fix: rebuild hormonal sleep architecture. Bio-Avail Omega+ calms the nervous system and helps regulate cortisol and circadian rhythm. Bio-Avail Collagen+ provides the amino acids and structural proteins needed for estrogen metabolism, neurotransmitter synthesis, and overnight repair.

One product restores rhythm. The other rebuilds recovery. Together, they restore deep, natural, hormone-safe sleep.

Formulated for Women in Hormonal Transition

After working with thousands of women who couldn't sleep through the night—especially during perimenopause and menopause—Chris designed this system to address hormonal sleep disruption at its root.

No melatonin. No hormones. No dependency. Just the nutrients and signaling support your body needs to rest, repair, and rebalance.

Harness Years of Clinical Experience and Proven Science

The Hormonal Sleep Rescue System is backed by clinical results:

• ThymoQuin™ black seed oil: shown to increase total sleep time and reduce sleep latency

• NovaSOL® curcumin: supports inflammation modulation and circadian regulation

• Collagen peptides: rich in glycine, proline, and hydroxyproline to support deeper sleep and hormonal repair

Each ingredient is selected for purity, potency, and compatibility with women in hormonal transition—so you can sleep deeper and wake brighter.

Discover the Hormonal Sleep Rescue System Advantage

 
Typical Sleep Aids
Root Cause Approach
Circadian + Cellular + Hormonal
Sedation only
Grogginess
None
Common
Long-Term Use
Safe & Non-Habit Forming
Tolerance builds
Ingredient Quality
Clinically validated, therapeutic doses
Often pixie-dusted
Holistic Support
Sleep + Hormones + Skin + Mood
Sleep only
Designed For
Women in hormonal transition
Generic users
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Meet Chris Kresser, your
Trusted Health & Wellness Guide

Founder & Functional Medicine Clinician

  • Globally renowned expert with over 15 years of experience
  • Dedicated to helping people improve their health by addressing modern challenges and nutrient gaps

Author & Educator

  • Treated thousands of patients
  • Trained more than 2,000 healthcare professionals
  • Gained valuable insights into functional medicine and nutrition
Hormonal Sleep Rescue System

Unlock Your Optimal Health

Support hormonal balance. Reclaim restorative sleep.
The Hormonal Sleep Rescue System — Sleep Deeper. Wake Brighter.

Try Now — Save 30% on Your First Subscription

Good For You—And the Planet

You can't have healthy humans without a healthy planet. That's why Adapt Naturals is working toward zero plastic and landfill waste in our supply chain.

In the fall of 2023, we started transitioning our packaging to 100% compostable, stand-up pouches. They're made from cellulose (wood pulp) and are free of PLA, BPA, PFAS, phthalates, and other harmful chemicals. They're printed with non-toxic, compostable ink. The pouches are so clean and biodegradable that you can put them in your backyard or curbside compost bin!

Our sustainable packaging initiative will prevent over 120,000 plastic bottles from ending up in a landfill or the oceans. Thank you for being part of the solution and helping Adapt Naturals protect the beauty of our natural environment!

Your Questions Answered

Most women notice improvements within 7 days, especially fewer nighttime wakeups. Full benefits typically unfold in 2-4 weeks as sleep architecture resets.

No. There are no sedatives or synthetic sleep hormones. You'll wake feeling clear and alert.

Yes. Omega+ restores circadian rhythm and reduces cortisol spikes. Collagen+ supports deeper sleep and hormonal repair. Together, they restore healthy sleep cycles.

Yes. These are foundational nutrients your body uses daily. No habit-forming compounds. Many women continue daily use for years.

No problem. Try it for 60 days. If you're not sleeping better, we'll give you a full refund—no questions asked.

  • 5 stars: 0 (0%)
  • 4 stars: 1 (25%)
  • 3 stars: 1 (25%)
  • 2 stars: 0 (0%)
  • 1 star: 2 (50%)
N
Niki Waltonen
No improvement yet

I have not noticed any improvement in the quality of my sleep thus far.

Hey Niki,

Thank you for being honest about where you are at and we are sorry to hear you have not noticed improvement yet. The Hormonal Sleep Rescue System works through a different mechanism than most sleep supplements, the Bio-Avail Omega+ supports healthy circadian rhythm function through a precise EPA to DHA ratio and the ThymoQuin™ black seed oil has shown promising results for sleep quality in recent research, while the Bio-Avail Collagen+ delivers 10 grams of grass-fed collagen rich in glycine which supports relaxation and sleep quality when taken about an hour before bed.
That said results can take 2 to 4 weeks to build and how you are taking it matters a lot. If you are not already taking the collagen about an hour before bed mixed into something warm that can make a real difference. Please reach out to our support team and we would love to help troubleshoot your timing and dosage to give it the best possible chance. And as always we back everything with our 90 day no questions asked refund policy so you have plenty of time!

B
Becky Way
Better sleep

I have noticed an improvement in my sleep after my first week. Chronic insomniac for years and years. Used to wake up 1-2 hours in the middle of the night. Now, I’m not getting 8 hours of sleep yet but I do not have those devastating 2 hour awake windows. Definitely going to reorder

Hi Becky,

This is so wonderful to hear! Thank you for sharing your experience with us.
We know how exhausting chronic insomnia can be, especially those devastating middle-of-the-night wake windows that feel endless. The fact that you're noticing improvement after just your first week with the Hormonal Sleep Rescue System—combining Bio-Avail Collagen+ and Bio-Avail Omega+—is really encouraging progress.
Sleep often continues to improve with consistent use as your body's stress response and inflammation become more balanced. You may find yourself getting closer to those full 8 hours as you continue with the stack. We're so glad it's making a real difference for you.
Thank you for trusting us with your sleep and for planning to reorder. Here's to many more restful nights ahead!

K
Kathi Tolle
Sleep Rescue

I’m giving the product only 3 stars because I’ve been using it for a couple of weeks. From what I have read it takes at least 30-60 days. On the very positive side this is the first collagen I have tried that virtually has no taste.

Hi Kathi,

Thank you for your honest feedback. You’re right—many of the ingredients in the Hormonal Sleep Rescue System, including collagen, work best with consistent use over several weeks. We’re glad to hear you’re enjoying the taste-free collagen, which makes it easy to add to your routine. If you decide it’s not the right fit after giving it more time, please remember you’re covered by our 60-day money-back guarantee.

M
Mary Jewell
Tastes good, but no help getting to sleep.

I tried various dosages of this drink, but did find an amount that helped me get to or stay asleep. But it tastes good!

Hi Mary,

Thank you for trying Hormonal Sleep Rescue System. We’re glad you enjoyed the flavor, though we’re sorry it hasn’t yet met your expectations for sleep support. Everyone’s body responds differently, and consistency over time can be key. Please know you’re covered by our 60-day money-back guarantee—we want you to feel confident in your purchase.