Your FREE Bio-Avail Colostrum+ will automatically be added at checkout

15,800+ Happy Customers

Spore-Forming Probiotics, Next-Generation Prebiotics, Patented Postbiotics, and Targeted Polyphenols


The first and only 4-in-1 microbiome support formula that replaces an entire cabinet of gut supplements with one comprehensive solution.


✓ 4-in-1 formula with probiotics that actually survive stomach acid


✓ Transform bloating, brain fog, and energy crashes within weeks


✓ Clinically-proven ingredients used by thousands of patients

✓ Optimize your microbiome and strengthen intestinal barrier integrity

Get Biome Protect Now
  • Free Shipping
  • 60-day Returns

See What Others Are Saying About Biome Protect

  • "I’ve only been taking Biome Protect for a week and already notice significant results. I was struggling with bloating and constipation after meals, and within a few days have much healthier, easier, and fuller BMs. I also feel a little more energy after my meals. Looking forward to more benefits with longer use."

    —Mary

  • "I have been told I have IBS so I've struggled with bloating and constipation for years. I tried [competitor probiotic] for a few months but it seemed to just stop working as well. I tried Adapt because I like that its not just about the gut but focuses on the gut. Its been a few weeks and it's already working better. I'm regular, no bloating and I feel good all around!"

    —Jasmine

  • "I definitely noticed a difference since starting Biome Protect and believe it’s due to the type of probiotic strain used. Daily bowel movements come easier, are better formed and bloating and gut uneasiness lessened. So glad to have tried this product that I’ll continue using."

    —Paula

Introducing Biome Protect: The First 4-in-1 Microbiome Support Formula

Biome Protect is the first and only product on the market that combines all four essential elements your gut needs to thrive in one comprehensive formula—what we call "Gut Health 3.0".

Unlike other gut health supplements that only provide basic probiotics (which die in stomach acid) or require you to take multiple products, Biome Protect includes:

✓ Spore-forming probiotics that survive digestion

✓ Next-generation prebiotics that work at 1/300th the dose

✓ Patented postbiotics that fuel your gut cells

✓ Targeted polyphenols from ancestral sources

Biome Protect is the clinical breakthrough that replaces an entire cabinet of gut supplements with one scientifically-formulated solution.

Get Biome Protect Now

What makes Biome Protect stand out?

  • Probiotics that survive stomach acid

    Biome Protect contains Bacillus coagulans, a spore-forming probiotic that survives stomach acid (unlike 95% of regular probiotics). This means the beneficial bacteria actually reach your intestines alive, where they can improve digestive comfort, enhance immune function, and even boost cognitive performance.

  • Prebiotics without the bloating

    Biome Protect features PreforPro®, a next-generation prebiotic that works at just 15 mg—that's 1/300th the dose of traditional fiber prebiotics. It increases good bacteria up to 6-fold without causing the bloating, gas, and discomfort typical of fiber-based prebiotics.

  • Postbiotics that fuel your gut

    Biome Protect includes CoreBiome® tributyrin, a patented form of butyrate that survives stomach acid and delivers this essential fuel throughout your entire digestive system. Butyrate directly energizes intestinal cells, strengthens the gut barrier, and supports healthy immune response.

  • Polyphenols from ancestral sources

    Biome Protect contains targeted polyphenols from cranberry, pomegranate, grape, and blueberry—the same compounds our ancestors consumed regularly. These specific polyphenols increase beneficial bacteria like Akkermansia, enhance butyrate production, and optimize your microbiome at the cellular level.

Formulated to Transform Your Gut Health from the Inside Out

After treating thousands of patients over 15 years, I discovered why most gut health solutions fail—and created the clinical breakthrough that has helped thousands of people thrive. Biome Protect was formulated to address the root causes of gut dysfunction, not just mask symptoms.

Unlike traditional approaches that rely on basic probiotics (which die in stomach acid) or require multiple supplements working against each other, Biome Protect provides four synergistic elements that enhance each other's effectiveness. This "Gut Health 3.0" approach optimizes your microbiome, strengthens your gut barrier, and supports whole-body health.

Biome Protect promotes better digestion, sustained energy, mental clarity, stronger immunity, and balanced mood—transforming your health from the foundation up.

Here are some benefits you can expect from this one-of-a-kind product:

✓ Eliminates bloating and digestive discomfort. Say goodbye to the uncomfortable fullness, gas, and unpredictable digestion that disrupts your day. Feel light, comfortable, and confident after meals.

✓ Restores consistent energy levels. No more afternoon crashes or brain fog. Experience sustained mental clarity and physical energy throughout your entire day.

✓ Strengthens your immune resilience. Get sick less often and bounce back faster when you do. Build robust defenses against whatever life throws your way.

✓ Promotes clearer skin and balanced mood. Watch as skin issues clear up and mood swings stabilize. Feel like yourself again—calm, focused, and radiantly healthy from the inside out.

Get Biome Protect Now
  • Free Shipping
  • 60-day Returns

Biome Protect contains:

SPORE-FORMING PROBIOTICS (BACILLUS COAGULANS)

SPORE-FORMING PROBIOTICS (BACILLUS COAGULANS)

2 billion CFU of Bacillus coagulans that survive stomach acid. Unlike 95% of regular probiotics that die before reaching your intestines, these spore-forming bacteria create a protective shell and activate exactly where needed for maximum effectiveness.

NEXT-GENERATION PREBIOTICS (PREFORPRO®)

NEXT-GENERATION PREBIOTICS (PREFORPRO®)

15 mg of PreforPro® bacteriophages that work at 1/300th the dose of fiber prebiotics. Selectively targets unwanted bacteria while increasing beneficial species up to 6-fold—without any bloating, gas, or digestive discomfort.

PATENTED POSTBIOTICS (COREBIOME®)

PATENTED POSTBIOTICS (COREBIOME®)

300 mg of CoreBiome® tributyrin, a time-released form of butyrate that survives stomach acid. Directly fuels intestinal cells, strengthens the gut barrier, and supports healthy immune response throughout your entire digestive system.

TARGETED POLYPHENOLS

TARGETED POLYPHENOLS

Concentrated extracts from cranberry, pomegranate, grape, and blueberry. These ancestral compounds increase Akkermansia muciniphila, enhance butyrate production, and optimize your microbiome at the cellular level.

Biome Protect gives you 4 clinically-proven gut health ingredients in a single product—at a significantly lower price than you'd pay for them separately.

GET BIOME PROTECT NOW

Adapt Naturals Biome Protect

Bio-Avail Biome Protect is the most comprehensive gut health formula on the market. No other product combines probiotics, prebiotics, postbiotics, and polyphenols in one scientifically-formulated solution.

  • 4-in-1 formula that replaces an entire cabinet of gut supplements
  • Spore-forming probiotics that actually survive stomach acid
  • Next-generation prebiotics that work without bloating
  • Patented postbiotics that fuel your gut cells directly
  • Targeted polyphenols from ancestral sources
  • Formulated by globally-renowned Functional Medicine clinician Chris Kresser
  • Made without gluten and GMOs
  • Manufactured in the US in a certified GMP facility

Signs You Need Biome Protect

Gas, bloating, or other digestive problems

Brain fog, poor focus, or mental fatigue

Skin issues that seem unrelated to diet

Mood swings, anxiety, or feeling "off"

Getting sick more often than you should

Irregular bowel movements or inconsistent stool quality

What You'll Feel Using Biome Protect

  • Better digestion and no more bloating

  • Mental clarity and sharper focus

  • Stronger immune defenses against daily challenges

  • Balanced mood and emotional wellbeing

  • Clearer, healthier-looking skin

  • Regular, consistent bowel movements

  • Support maintaining normal weight and metabolic function

Meet Chris Kresser, your
Trusted Health & Wellness Guide

Founder & Functional Medicine Clinician

  • Globally renowned expert with over 15 years of experience
  • Dedicated to helping people improve their health by addressing modern challenges and nutrient gaps

Author & Educator

  • Treated thousands of patients
  • Trained more than 2,000 healthcare professionals
  • Gained valuable insights into functional medicine and nutrition

"I'm excited about Adapt Naturals and Bio-Avail Multi. Chris is a leading clinician, educator, and researcher in the Functional Medicine space. I've learned a lot from him about nutrition and supplements over the years, and I know his products are fueled by high-quality, evidence-based ingredients you can trust."

Dr. Mark Hyman MD

14-time New York Times best selling author and founder of the Cleveland Clinic Center for Functional Medicine

"Chris Kresser is one of the sharpest minds in the functional / integrative medicine space. I have reached out to Chris many times when working to unravel my own health journey and his insights have always been incredible. Given all that, I'm super excited for the release of Adapt Naturals line of supplements, especially Bio-Avail Multi. Chris and I are aligned in that we believe the bulk of our nutrition should come from whole, minimally processed foods, but we also recognize that the right supplement, at the right time can 'change everything.'"

Robb Wolf

Former research biochemist and 2-time New York Times bestselling author of The Paleo Solution and Wired To Eat.

"I can't think of a better person to formulate supplements than Chris Kresser. I trust his ability to skillfully combine ancestral wisdom with modern science and cutting-edge research. Taken together, the products offer a well-rounded and complete way to boost your nutritional status. I am excited about this high-quality, comprehensive new product line - I strongly recommend it!"

Dr. Akil Palanisamy MD

Harvard-trained physician, author, speaker, and holistic medicine expert in integrative and functional medicine

"I trust Chris Kresser with my life, and you will too."

Sara Gottfried MD

Harvard Trained Physician and New York TimesBestselling author of The Hormone Cure

Choose Your Biome Protect Package

FREE pouch of Bio-Avail Colostrum+ included. Plus, free shipping when you order 3 or more pouches!

 30-Day Supply

1 Pouch of Biome Protect +

1 FREE Bio-Avail Colostrum+ pouch

$127.87 $57.93
You're saving: $69.94
Buy Now

60-Day Returns

Most Popular
Save 30%
90-Day Supply

3 Pouches of Biome Protect +

1 FREE Bio-Avail Colostrum+ pouch

$243.73 $159.61
You're saving: $84.12
Buy Now

Free Shipping • 60-Day Returns

Save 40%
180-Day Supply

6 Pouches of Biome Protect +

1 FREE Bio-Avail Colostrum+ pouch

$417.52 $250.51
You're saving: $167.01
Buy Now

Free Shipping • 60-Day Returns

About your FREE Bio-Avail Colostrum+

For patients with severe gut permeability issues, I discovered that adding colostrum accelerated healing dramatically. Bio-Avail Colostrum+ provides:

✓ Immunoglobulins that neutralize harmful bacteria

✓ Lactoferrin for natural antimicrobial support

✓ Growth factors that directly repair intestinal lining

✓ Enhanced with beta-glucan for immune training

When combined with Biome Protect, it creates powerful synergy: Biome Protect optimizes your microbiome while Bio-Avail Colostrum+ repairs and seals your gut barrier.

60-Day Money Back Guarantee

60-Day Money Back Guarantee

We're confident you'll love our products, but if you're not completely satisfied, we offer a 60-day, 100% money-back guarantee on all purchases. Simply contact us for a full refund, no questions asked. Buy with confidence knowing you're covered by our guarantee.

The Adapt Naturals Standard

The Adapt Naturals Standard

In our increasingly toxic world, the last thing you want to worry about is a lot of artificial junk in your supplements. Adapt Naturals supplements are made with the cleanest possible ingredients, without gluten or GMOs. Our products are manufactured in a U.S. facility that meets the NSF’s rigorous GMP regulatory standards.

Third Party Lab-Tested

Third Party Lab-Tested

At Adapt Naturals, all of our products are third-party tested and validated, and we are always happy to share these results with customers. We want you to have full confidence that you’re getting exactly what you think you are with each purchase.

Learn More

Your Questions Answered

Take 2 capsules daily, preferably with a meal. For best results, take consistently every day.

No, Biome Protect is shelf-stable and does not require refrigeration. Store in a cool, dry place.

Some people may notice improvements in digestion and energy within a few days. However, for full benefits, we recommend taking Biome Protect consistently for at least 30-60 days.

Yes, Biome Protect is designed to complement other supplements, including other probiotic strains. However, if you're taking any medications, please consult with your healthcare provider before starting any new supplement regimen.

Yes, Biome Protect is formulated for safe, long-term use. The ingredients are naturally occurring compounds that support overall gut health and wellness.

If you are pregnant, nursing, or taking blood thinners or anti-coagulant medications, please consult with your healthcare provider before using Biome Protect.

Yes, all Adapt Naturals products, including Biome Protect, undergo rigorous third-party testing for purity and potency. Most importantly, we transparently share these results with our customers by posting Certificates of Analysis (CoAs) and test results on our website. This level of openness is almost unheard of in the supplement industry. It allows you to see exactly what’s in the product you’re putting into your body.Click here to view the most recent CoA and test results.

Customer Reviews

Based on 158 reviews
83%
(131)
8%
(13)
3%
(5)
2%
(3)
4%
(6)
D
Dallas Bogert
I can feel the difference

I’ve been taking biome protect for two weeks now the first week I didn’t feel any different the second week I can feel the difference as things are working yet. It takes a while for things to work. My Microbiome was not wrecked in one day. It’s happened overtime so I have to give time to get my health back and these have been helping truly, I feel a difference within those first two weeks less bloating, more consistent bathroom times and all I can do is hope that it gets better and better the longer I take them thank you.

Hi Dallas,

Thank you for such a thoughtful, realistic perspective! You’re absolutely right—rebuilding the microbiome takes time, and consistency is key. We designed Biome Protect with carefully selected probiotic strains, prebiotics, postbiotics and gut-healing polyphenols to support long-term digestive balance, reduce bloating, and improve regularity. We’re thrilled you’re already feeling the shift and rooting for even more progress ahead!

I
Ivellisse Quinones
Biome Protect

I bought this supplement and I have been using it for about two (2) weeks. I have noticed that I don't have that urge to snack frequently and feel satisfied longer. It has helped me to regularize with my gut. I feel with more mental alertness and less tired during the day. Thanks.

Hi Ivellisse,

This is wonderful feedback—thank you! Biome Protect was formulated not only to support gut regularity but also to positively influence satiety and energy through the gut-brain axis. We’re so glad you’re experiencing steadier energy, less snacking, and improved focus. Keep us posted on your journey!

S
Sarah H.
Better than anything I’ve tried.

I have my diet and lifestyle dialed. I am approaching menopause and have hashimotos and rosacea so I like to support my body with probiotics. I’ve tried Seed and pendulum which were good for a while but Adapts Biome Protect is better than anything I’ve ever tried. I recommend it to all of my clients, friends and family now. 5 stars!

Hi Sarah,
Your review truly made our day — thank you! Biome Protect combines probiotics, prebiotic, polyphenols, and postbiotics to support gut balance in a holistic way. We’re honored that it’s been so effective for you and that you’re sharing it with your community. Your trust means the world to us.

j
jess
Biome Protect

recommended to me by my herbalist for chronic IBS symptoms and symptoms that were associated with an imbalance in microbiome. I felt shifts after the first day- less bloat and heaviness in the gut, less digestive distress overall, and increase in hunger came back, shift in mood, heavy mental states also shifted, and i noticed an increase in stamina and energy levels. i have tried all things nutrition and all kinds of products and this one by far has had the most positive impact. i feel like my gut is finally in a healing and recovery mode. i will def by this again.

Hi Jess,

Your story is so inspiring! Thank you for sharing it in such detail. We formulated Biome Protect with targeted probiotics, prebiotics, postbiotics and polyphenols to rebalance the gut, ease digestive distress, and support the gut-brain connection. It’s incredible to hear how quickly you felt shifts in your energy, mood, and overall digestive comfort. We’re honored to be part of your healing journey and we hope to continue to be! Welcome to the Adapt Naturals family!

T
Tyler Holt
Best feeling gut ever!

My gut has never felt better! Thank you!

Hi Tyler,
This makes us so happy to hear — thank you! We’re thrilled Biome Protect is helping you feel your best!

123